Man's Best Friend is a UK VHS release by Guild Home Video on 7th November 1994.
- Ally Sheedy as Lori Tanner, a TV personality who becomes Max's adoptive owner.
- Lance Henriksen as Dr. Jarret, a scientist at EMAX who is Max's original owner and tormentor.
- Robert Costanzo as Detective Frankie Kovacs, a detective who investigates Max.
- Fredric Lehne as Perry, Lori's boyfriend and Max's arch-rival. Max's second tormentor and near victim.
- John Cassini as Detective Emilio Bendetti, a detective who investigates Max
- J.D. Daniels as Rudy, Lori's young next-door neighbor.
- William Sanderson as Ray, a junkyard operator, Max's fifth tormentor and victim.
- Trula M. Marcus as Annie
- Robin Frates as Judy Sanders, an employee at EMAX who is killed by Max.
- Frank Welker as the vocal effects of Max, a genetically altered Tibetan Mastiff and also Ed, a parrot owned by Perry.
- Rick Barker as Mailman, Max's fourth tormentor and victim.
- Mickey Cassidy as Paperboy, Max's third tormentor.
- Thomas Rosales, Jr. as Mugger, a man who robs Lori and becomes Max's second victim.